Journal article
Mathematical model of TGF-βsignalling: Feedback coupling is consistent with signal switching
S Khatibi, HJ Zhu, J Wagner, CW Tan, JH Manton, AW Burgess
BMC Systems Biology | BMC | Published : 2017
Abstract
Background: Transforming growth factor β (TGF-β) signalling regulates the development of embryos and tissue homeostasis in adults. In conjunction with other oncogenic changes, long-term perturbation of TGF-β signalling is associated with cancer metastasis. Although TGF-β signalling can be complex, many of the signalling components are well defined, so it is possible to develop mathematical models of TGF-β signalling using reduction and scaling methods. The parameterization of our TGF-β signalling model is consistent with experimental data. Results: We developed our mathematical model for the TGF-β signalling pathway, i.e. the RF- model of TGF-β signalling, using the "rapid equilibrium assump..
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Awarded by Ludwig Institute for Cancer Research
Funding Acknowledgements
SK was supported by a Melbourne International Research Scholarship and a Melbourne International Fee Remission Scholarship from the University of Melbourne. AWB was supported by the Ludwig Institute for Cancer Research and NHMRC Program grant Number 487922.